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Quinidine Hemolytic Anemia in the Absence of Thrombocytopenia in a Patient with Hemoglobin D
Author(s) -
Bell C. A.,
Zwicker H.,
Lee S.,
Alpern H.
Publication year - 1973
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1973.tb05448.x
Subject(s) - coombs test , quinidine , medicine , hemolysis , hemolytic anemia , anemia , serology , hemoglobin , gastroenterology , antibody , immunology
A patient on quinidine therapy was found to have a positive direct Coombs test and low grade hemolytic anemia without thrombocytopenia. The serum and red cell eluates contained an antibody which reacted by indirect Coombs technic against red cells presensitized with quinidine gluconate. The serum also contained weak anti‐Sd a . The hemolytic anemia, anti‐Sd a , and positive direct Coombs test disappeared three months after the drug was discontinued. The serologic findings are described. An incidental finding of hemoglobin D is also noted, and its relationship to the hemolysis is considered.