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Variations in the Agglutinability of Red Blood Cells from Patients with Hematologic Disorders
Author(s) -
Buchholz D. H.,
Bove J. R.
Publication year - 1973
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1973.tb05433.x
Subject(s) - hematologic disorders , anemia , medicine , immunology , lymphoma , hemagglutination , platelet , antibody
The agglutinability of red blood cells from patients with various hematologic disorders was compared with that of erythrocytes from normal persons by quantitative hemagglutination in the ABH blood group system. Red blood cells from six patients with hypoplastic anemia or metastatic marrow disease as well as normal reticulocytes (five experiments) were less agglutinable than normal mature cells. Erythrocytes from one patient with lymphoma and an acquired hemolytic anemia showed enhanced agglutinability. Our data suggest that changes in erythrocyte reactivity may be more common than suspected, although usually undetected by less sensitive methods.