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The Incidence of Antibodies to Leukocytes and Gammaglobulin IgG and IgA in a Population of Multitransfused Southern African Negroes
Author(s) -
Vos G. H.,
Downing H. J.,
Vos D.
Publication year - 1973
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1973.tb04474.x
Subject(s) - incidence (geometry) , antibody , medicine , immunology , population , gamma globulin , environmental health , physics , optics
Posttransfusion samples of serum from Southern African Negroes who suffered mild to severe hypersensitivity reactions possessed more antileukocyte than antiglobulin antibodies to IgG and IgA. On the other hand, multitransfused patients who did not develop adverse transfusion reactions showed a lower incidence of antileukocyte antibodies and a higher incidence of antiglobulin antibodies. The reduced incidence of antiglobulin antibodies found in posttransfusion samples of serum from patients who developed transfusion reactions may reflect in vivo consumption of such antibodies by antigenin‐excess conditions. For the increased incidence of antileukocyte antibodies in the same group of patients the infusion of relatively small amounts of incompatible leukocytes appears to be inadequate to reduce the corresponding antibody levels.