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Polybrene‐induced Red Blood Cell Aggregation In Vitro
Author(s) -
Dembitzer H. M.,
Oberhardt B. J.,
Duffy J. L.,
Lalezari P.
Publication year - 1972
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1972.tb05891.x
Subject(s) - extracellular , in vitro , intracellular , membrane , red blood cell , transmission electron microscopy , scanning electron microscope , biophysics , chemistry , cell , blood cell , microbiology and biotechnology , biology , biochemistry , immunology , materials science , nanotechnology , composite material
Human erythrocytes, aggregated by non‐immunological means, were studied by both scanning and transmission electron microscopy. Cells within the Polybrene®‐induced aggregates appeared spheroidal at their free surfaces and flattened at their interfaces. The outer leaflets of apposing plasma membranes were found to approach each other very closely at several points so that no measurable intervening extracellular space was discernible. This finding is consistent with the concept that Polybrene acts by diminishing intercellular distances.