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Continuous Flow Filtration—Leukopheresis
Author(s) -
Djerassi I.,
Kim J. S.,
Suvansri U.,
Mitrakul C.,
Ciesielka W.
Publication year - 1972
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1972.tb05889.x
Subject(s) - filtration (mathematics) , size exclusion chromatography , chromatography , granulocyte , in vitro , continuous flow , donation , immunology , chemistry , medicine , intensive care medicine , biochemistry , mathematics , mechanics , enzyme , statistics , physics , economics , economic growth
A practical method for continuous granulopheresis of normal individuals, based on selective filtration–adsorption of the granulocytes, was developed. Large numbers of granulocytes (up to 0.6 × 10 11 ) can thus be separated and collected under sterile conditions from one donor on a single donation. The cells are viable by in vitro criteria including eosin exclusion and phagocytic ability. The procedure is tolerated well by the donors. The granulocytes separated by filtration–leukopheresis are suitable for clinical studies.