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Quinine‐induced Thrombocytopenic Purpura Due to an IgM and an IgG Antibody
Author(s) -
Eisner E. V.,
Korbitz B. C.
Publication year - 1972
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1972.tb04451.x
Subject(s) - quinine , antibody , medicine , thrombocytopenic purpura , purpura (gastropod) , immunology , drug , gamma globulin , immunoglobulin m , immunoglobulin g , platelet , malaria , pharmacology , biology , ecology
Severe thrombocytopenia developed in a young man following the ingestion of quinine water. Quinine‐dependent antiplatelet antibodies were found in both IgM and IgG components of the patient's immunoglobulins. The data demonstrate that drug‐related antiplatelet activity is not a unique property of 7 S gamma globulins, and that both IgM and IgG antibodies may occur simultaneously in drug‐related thrombocytopenia.