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Serum Creatinine and Creatinine Clearance after Transfusion with ACD–Adenine Blood and ACD Blood
Author(s) -
Westman B.J.M.
Publication year - 1972
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1972.tb00028.x
Subject(s) - creatinine , nephrotoxicity , medicine , urology , renal function , blood transfusion , surgery , kidney
In order to evaluate the nephrotoxic effect of adenine which is used to improve the viability of preserved erythrocytes, massively transfused patients undergoiag open heart surgery were investigated. The serum creatinine level and creatinine clearance were recorded during the eight‐day period following the operation. Serum creatinine was tested repeatedly in 118 patients receiving a mean of 13.0 units of ACD–adenine blood and 49 patients receiving a mean of 15.9 units of ACD–blood. For the studies of creatinine clearance two additional groups of ten patients each were used. The patients in the first group were given a mean 17.5 units of ACD‐adenine blood and the patients in the second group were given a mean of 16.6 units of ACD blood. Serum creatinine increased to about 150 percent of the preoperative value on the first postoperative day without any significant difference between the two groups. The preoperative values of serum creatinine were then reached within a few days. Postoperatively, there was only a slight decrease of clearance values in the two groups. On one occasion there was a significant difference (P < 0.05) in serum creatinine between the ACD–adenine and the ACD–group. All other differences were not significant and thus no evidence of nephrotoxic effect of the adenine added to the ACD solution. The estimated maximal amounts of adenine administered throngh the transfusions varied between 2 and 15 mg per kg body weight. There was no tendency of higher serum creatinine values in patients receiving higher doses of adenine.