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Patterns of Endogenous Platelet Serotonin Release
Author(s) -
Aledort L. M.,
Gilbert H. S.,
Puszkin E.
Publication year - 1971
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1971.tb04413.x
Subject(s) - endogeny , serotonin , platelet , thrombin , adenosine diphosphate , 5 ht receptor , connective tissue , chemistry , adenosine , medicine , platelet aggregation , endocrinology , pharmacology , biochemistry , receptor , pathology
The release of endogenous serotonin (5HT) from the platelets of normal human subjects was studied using adenosine diphosphate (ADP), thrombin, and connective tissue (CT) as aggregating agents. Clot retraction was found to release from 60 to 100 per cent of available platelet 5HT. Of the aggregating agents studied, only connective tissue was accompanied by the release of endogenous SHT in all subjects. Low concentrations of ADP gave no release, and high concentrations of ADP as well as thrombin‐induced aggregation gave release in the minority of subjects. The pattern of release of endogenous 5HT in response to aggregating agents was found to differ from results of studies reported by others 18, 19 using exogenous radioactive 5HT.