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Comparative Sensitivity of Complement Fixation, Counterimmunoelectrophoresis, Radial, and Double Diffusion for Detection of Australia Antigen
Author(s) -
Holper J. C.,
Jambazian A.
Publication year - 1971
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1971.tb04395.x
Subject(s) - counterimmunoelectrophoresis , double diffusion , complement fixation test , diffusion , antigen , sensitivity (control systems) , materials science , medicine , immunology , virology , serology , antibody , physics , thermodynamics , electronic engineering , engineering
The comparative sensitivity of CF, CIEP, and radial and double diffusion tests were determined on specimens from a large institution, samples submitted to a clinical laboratory for Australia testing, and samples from a commercial blood banking operation. CF, CIEP, and radial diffusion were more sensitive systems for the detection of Au than double diffusion. However, the greater sensitivity of the CF, CIEP, and radial diffusion had only a small effect on the frequency of detection of positive specimens. This slight effect was probably due to the relatively low percentage of specimens with concentrations of Australia antigen below the detectability of the double diffusion system.