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G u , a Variant of G
Author(s) -
Beattie K. M.,
Neitzer G. M.,
Zanardi V.,
Zuelzer W. W.
Publication year - 1971
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1971.tb04394.x
Subject(s) - antibody , microbiology and biotechnology , antigen , biology , immunology
G u , analogous to D u and E u , is a weak variant of G appearing in a haplotype lacking C, D, and E but having e s . In a preliminary survey, the red blood cells ot three of 186 Negro blood donors found negative when tested for C, D (incuding D u ), and E were shown to be G u ‐positive when tested with anti‐CD by the antiglobulin technic. Fourteen additional examples from unrelated persons and five members of a family have been investigated in this study. All G u ‐positive individuals tested are VS‐positive, but V‐negative, and all are Negro. Although G cells show greater antibody uptake when used to absorb anti‐CD, G u cells elute anti‐G in substantially greater amounts than do G cells. Comparative studies demonstrate similarity of specificity but a difference of avidity, which could be due to the influence of e s (VS) in cis position. G u ‐positive bloods have been shown to stimulate the production of anti‐G in Rh‐negative recipients. The test for G u can be incorporated in the test for D u by substituting anti‐CD or anti‐CDE for anti‐D serum.