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Effect of Plasma Removal on Blood Stored in ACD with Adenine
Author(s) -
Shields C. E.
Publication year - 1971
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1971.tb04390.x
Subject(s) - blood preservation , blood transfusion , whole blood , cryopreservation , fresh frozen plasma , blood plasma , hemoglobin , blood volume , medicine , chemistry , blood units , red blood cell , andrology , surgery , anesthesia , biology , platelet , embryo , microbiology and biotechnology
An evaluation of the effects of plasma in blood preservation was carried out on units of blood from which the plasma had been removed at different times during storage and on other units in which the plasma volume had been replaced by saline. Blood was either collected in ACD and stored for 14 or 21 days, or collected in ACD supplemented with adenine and stored for 21 or 42 days. These units were given in homologous transfusions to human volunteers. Autologous transfusions were used for separate groups studied at the same time. Stored units reflected progressive chemical deterioration with increasing storage. The elevation of plasma hemoglobin concentration was observed to be greater in units stored as packed cells. Average posttransfusion survival values for blood stored for 21 or 42 days were higher for adenine‐supplemented blood than for blood in ACD alone, Autologous transfusions with ACD‐adenine blood stored for 21 or 42 days survived for the same length of time as did homologous transfusions. Packed cells with plasma removed shortly after collection had the poorest survival. The similarity of values obtained for cells without plasma suggested that plasma was not particularly involved with the preservation of blood for up to 21 days of storage as tested by red blood cell survival. Improved preservation obtained with adenine was observed even when plasma was removed. Hence, the usefulness of plasma for component therapy may well outweigh its role in blood storage.