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Fibrinogen and Fibrin Degradation Products in Hemolytic Transfusion Reactions
Author(s) -
Sack E. S.,
Nefa O. M.
Publication year - 1970
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1970.tb00751.x
Subject(s) - fibrinogen , fibrin , medicine , coagulation , heparin , disseminated intravascular coagulation , hemorrhagic diathesis , bleeding diathesis , clotting factor , coagulopathy , platelet , surgery , gastroenterology , immunology
Three patients who received incompatible transfusions are reported. Two developed a generalized bleeding diathesis and died. Clotting studies showed disseminated intravascular coagulation. Fibrinogen and fibrin split products were found in extremely high amounts as a result of secondary activation of the fibrinolytic system following the intravascular coagulation episode. One patient was treated with heparin with cessation of the hemorrhage. Prompt treatment with heparin should be the therapy of choice for the bleeding tendency which accompanies hemolytic reactions.