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Analysis of Erythrocyte Survival Curves Obtained Simultaneously by 51 Cr and an Automated Differential Agglutination Technic
Author(s) -
Szymanski I. O.,
Valeri C. R.
Publication year - 1970
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1970.tb00746.x
Subject(s) - agglutination (biology) , isotopes of chromium , chromium , medicine , immunology , nuclear medicine , chemistry , antibody , organic chemistry
Using both a radioactive chromium and an automated differential agglutination (ADA) technic donor erythrocyte survivals were measured in 19 subjects. The data were analyzed to determine the presence of age‐dependent (linear) and random (exponential) destruction. The erythrocyte lifespan was calculated from the rate of linear destruction. In all cases it was possible to estimate the erythrocyte lifespan with the ADA technic. Significant random destruction of red blood cells was observed in nine patients. With the 51 chromium technic it was possible to estimate the erythrocyte lifespan in only ten cases; these values were similar to those obtained with the ADA technic. It was not possible to determine the erythrocyte lifespan in the remaining nine cases; the best estimates were too large. Our inability to measure erythrocyte lifespan satisfactorily with the 51 chromium technic may have been related to the preferential labeling of young red blood cells in vitro .