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Behavior of Previously Frozen Erythrocytes Used during Open‐heart Surgery
Author(s) -
Valeri C. R.,
Bougas J. A.,
Talarico L.,
Emerson C. P.,
Didimizio T.,
Pivacek L.
Publication year - 1970
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1970.tb00737.x
Subject(s) - extracorporeal circulation , fresh frozen plasma , medicine , partial thromboplastin time , creatinine , hemoglobinuria , prothrombin time , fibrinogen , platelet , blood preservation , urine , surgery , hemolysis , andrology
Glycerolized human red blood cells that had been stored in the frozen state at ‐80 C up to six months, thawed, and washed by the dilution‐agglomeration procedure of Huggins, were administered during extracorporeal circulation along with nonfrozen acid‐citrate‐dextrose‐(ACD) stored blood. Eleven patients who received both nonfrozen ACD‐stored blood and the previously frozen, washed, concentrated cells were compared with 14 patients who were given whole blood stored only in ACD. No significant differences were observed between the two groups in respect to platelet count, partial thromboplastin time, prothrombin time, or fibrinogen level. Higher plasma and urine hemoglobin levels were observed in the patients who received both blood stored in ACD and washed, previously frozen, concentrated red blood cells. Hemoglobinuria was observed in both groups but was not accompanied by significant differences in BUN or creatinine levels. There was no significant difference in morbidity or mortality between the two groups of patients.