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Platelet Increments and Their Relationship to Acidification
Author(s) -
Shively J. A.,
Jongh D. S.,
Isassi A. A.,
Freireich E. J.
Publication year - 1969
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1969.tb05536.x
Subject(s) - platelet , chemistry , platelet aggregation , in vitro , medicine , pharmacology , biochemistry
Acidification of platelet‐rich plasma to a pH of approximately 6.5 by the use of additional ACD anticoagulant solution before preparation of platelet concentrates results in a greater increment of the one‐hour posttransfusion platelet count and better clinical hemostatic effects when compared with preparations whose pH values are reduced to approximately 6.7 to 6.8. The latter preparations show greater tendency to aggregate spontaneously and a larger response to ADP in vitro than those at a pH of 6.5. If maximum recovery of platelets from a single donor is the primary objective, platelet‐rich plasma should be acidified to pH 6.5 before preparation of platelet concentrates.