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A New Method for Detection of Red Blood Cell Antibodies
Author(s) -
Lalezari P.
Publication year - 1968
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1968.tb02439.x
Subject(s) - autoanalyzer , agglutination (biology) , antibody , red blood cell , red cell , microbiology and biotechnology , chemistry , immunology , medicine , chromatography , biology
A new method for the detection of red blood cell antibodies has been developed. Polybrene®, a positively charged polymer, was utilized to produce agglutination of red blood cells. This agglutination could be reversed by the addition of hyper tonic salt solution. However, red blood cells remained agglutinated in the presence of antibodies. This principle was applied to antibody detection automated by AutoAnalyzer rG . The method has proved to be highly sensitive and has a wide spectrum of usefulness for the detection of both “complete” and “incomplete” antibodies.