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Studies on Release of Certain Enzymes from Human Platelets
Author(s) -
Mourad N.
Publication year - 1968
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1968.tb02437.x
Subject(s) - platelet , enzyme , centrifugation , chemistry , platelet aggregation , biochemistry , biology , immunology
The release of enzymes from platelets was used as an index of damage to platelet concentrates during their preparation. Enzyme release occurs when aggregated platelets are traumatized. Neither trauma nor aggregation alone produces enzyme release. Enzyme release is increased as the volume of the platelet concentrate is decreased. Aggregated platelets release their enzymes during resuspension whether aggregation is induced by ADP or low temperature. Enzyme release is minimized when platelet concentrates are prepared at 25 C and redispersed 20 to 30 minutes after centrifugation.