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The Lutheran Blood Groups: A Progress Report with Observations on the Development of the Antigens and Characteristics of the Antibodies
Author(s) -
Greenwalt T. J.,
Sasaki T. T.,
Steane E. A.
Publication year - 1967
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1967.tb05509.x
Subject(s) - antibody , hemolytic disease of the newborn (abo) , antigen , serology , cord blood , immunology , medicine , biology , fetus , genetics , pregnancy
Scoring titrations with anti‐Lu a on 81 members of the families of seven Lu(a+b—) propositi did not produce any evidence for the presence of Lu genes. In the Lu(a+b+) heterozygotes the Lu a antigen was only weakly expressed at birth increasing progressively during the first 15 years. The red cells of Lu(a+b—) children gave scores comparable to those of adults. The reactions of Lu(a—b+) cord cells were somewhat weaker than those of adults but the red cells of Lu(a+b+) infants reacted very weakly with anti‐Lu a . Four infants born to mothers with anti‐Lu b had no evidence of hemolytic disease due to this antibody. Serologic, immunochemical and ultrafiltration studies suggest that the examples of anti‐Lu b studied are mainly IgA. These observations can explain why no unequivocal examples of hemolytic disease of the newborn due to anti‐Lu b have been encountered.