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Studies on the Distribution of the Blood Group Antigen Do a (Dombrock) and the Characteristics of Anti‐Do a
Author(s) -
Polesky Herbert F.,
Swanson Jane L.
Publication year - 1966
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1966.tb04734.x
Subject(s) - antigen , antibody , blood group antigens , immunology , isoantibodies , in vivo , immune system , group a , blood transfusion , in vitro , medicine , distribution (mathematics) , biology , microbiology and biotechnology , genetics , mathematics , mathematical analysis
An antibody developing in Mrs. Dombrock following transfusion, defines a new blood group system. The antigen Do a , present in 64 per cent of Caucasians, has a lower frequency in Indians and Negroes. The immune characteristics of this antibody have been demonstrated by reactions in vitro and in vivo. It is to be expected that if Dombrock proves to be a two allele system, the antigen Do b will occur in 84 per cent of Caucasians.