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Antihemophilic Factor (AHF) Stability in Fresh Frozen Blood Bank Plasma
Author(s) -
Weaver Roy A.,
Langdell Robert D.
Publication year - 1966
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1966.tb04728.x
Subject(s) - fresh frozen plasma , blood bank , blood preservation , medicine , zoology , chemistry , andrology , biology , emergency medicine , platelet
One hundred randomly chosen units of fresh frozen blood bank plasma were assayed for antihemophilic activity (AHF). A wide range in AHF levels was observed. The variability appears to be due in part to different AHF levels of donors. Most of the units had as much as 30 per cent less AHF than was contained in unfrozen, freshly prepared plasma. There was no trend toward lower values in plasma frozen up to 15 weeks. Many factors contribute to the unpredictable loss of AHF. The effects of slow and rapid freezing on the AHF content of plasma were studied. Freezing of fresh bank plasma in a bath of liquid and in air are compared. Plasma freezes much more rapidly in liquid, with negligible loss of AHF. Freezing is considerably slower in air, and losses of 20 per cent or greater frequently occur.