Premium
An Evaluation of Anticoagulant Solutions Used in the Preparation of Platelet Concentrates *
Author(s) -
Kinlough Raelene L.,
Davey Martin G.,
Lander Harry
Publication year - 1966
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1966.tb04727.x
Subject(s) - platelet , anticoagulant , spleen , life span , yield (engineering) , chemistry , medicine , surgery , immunology , materials science , metallurgy , gerontology
Radiochromate‐labeled platelet concentrates have been prepared following collection of blood into solutions of EDTA, ACD (formula A), and a more acidic form of citrate‐dextrose—ACD ‘S’. Platelet yield was greatest when EDTA was used but following transfusion, relatively few platelets survived in circulation as viable units. In terms of over‐all efficiency both solutions of ACD were superior to EDTA. Platelet life span in circulation was unaffected by the anticoagulant used for the collection of blood and would appear to be influenced by both age‐dependent and random processes. Surface scintillation counting suggested that in man the majority of effete platelets are normally removed in the liver and that the spleen plays a secondary, but not unimportant, role in this process.