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Inhibition of Hemagglutinins by N‐Substituted Glycosylamines *
Author(s) -
Chattoraj Aparna,
Boyd William C.
Publication year - 1966
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1966.tb04715.x
Subject(s) - chemistry , antigen , stereochemistry , microbiology and biotechnology , biology , immunology
The inhibition reaction has been used to explore further the chemical nature of the Rh antigens, D, C and E, using a number of N‐substituted glycosylamines as inhibitors. A marked inhibition of the anti‐Rh sera by the p‐aminophenol compounds was noticed. Of the various compounds tested, p‐hydroxy‐N‐phenyl‐ d ‐galactosylamine seem to be the best inhibitor of anti‐D sera. The best inhibitor of the anti‐C was p‐hydroxy‐N‐phenyl‐ d ‐ma::nosylamine. Anti‐E was inhibited by this compound as well as by p‐hydroxy‐N‐phenyl‐ l ‐mannosylamine and p‐hydroxy‐N‐phenyl‐ l ‐glucosylamine. Activity of the l ‐sugar derivatives was observed, especially in the inhibition of anti‐E and anti‐D. The three Rh antigens seem possibly to show a basic resemblance in structure.