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Effect of Lactose, Dextran and Albumin on Recovery and Survival of Frozen Red Cells
Author(s) -
Strumia Max M.,
Strumia Paul V.,
Burns M. Elizabeth,
Dugan Ann,
Alter Burr,
Benner Richard
Publication year - 1965
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1965.tb02916.x
Subject(s) - lactose , albumin , dextran , mean corpuscular volume , chemistry , blood preservation , red cell , potassium , andrology , biochemistry , medicine , hemoglobin , organic chemistry
We have studied the effect of albumin and dextran, with and without previous modification with lactose, on the recovery and posttransfusion survival of red cells subjected to rapid freezing and thawing. Dextran and albumin have been found to protect red cells during freezing and thawing, with a recovery rate of 98.5 and 98.57%, respectively. A mean survival of 69.14% of red cells was obtained 24 hours posttransfusion when the red cells were treated with lactose, prior to freezing with dextran. A relationship has been found to exist between the mean corpuscular volume of the frozen red cells and the posttransfusion survival; potassium loss, stability, dimensional changes and O 2 dissociation of frozen red cells were determined.