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Survival of Factor XI in Vitro and in Vivo
Author(s) -
Horowitz Herbert I.,
Fujimoto Mitsu M.
Publication year - 1965
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1965.tb01201.x
Subject(s) - fresh frozen plasma , in vivo , medicine , andrology , whole blood , in vitro , surgery , chemistry , biology , biochemistry , platelet , microbiology and biotechnology
The rate of loss of factor XI was followed in ten units of whole blood during 21 days of storage at 4C. A rapid loss of 80 per cent of the total factor XI occurred during the first week of storage and correlated with the appearance of activated factor XI in the blood units. The in vivo survival of transfused factor XI was followed in two patients with a congenital deficiency of this factor who were given single infusions of 10 cc of fresh frozen plasma per kilo. A circulating half life of ten hours was found. Fresh whole blood or fresh frozen plasma should be used for replacement therapy of factor XI.