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Change in Platelet Factor 3 as a Means of Demonstrating Immune Reactions Involving Platelets: Its Use as a Test for Quinidine‐Induced Thrombocytopenia
Author(s) -
Horowitz Herbert I.,
Rappaport Herbert I.,
Young Robert C.,
FUJIMOTO MlTSU M.
Publication year - 1965
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1965.tb01182.x
Subject(s) - quinidine , platelet , complement fixation test , purpura (gastropod) , antibody , incubation , medicine , immunology , pharmacology , incubation period , thrombocytopenic purpura , immune thrombocytopenia , chemistry , biochemistry , biology , serology , ecology
An increase in platelet factor 3 activity of intact platelet‐rich plasma (PRP), measured as a shortening of the product I or Russell's viper venom time, has been found to accompany platelet damage. In the present study increased platelet factor 3 activity was found on incubation of PRP with hetero‐antibodies directed against platelets, as well as in incubation mixtures containing quinidine and the antibody of quinidine‐induced thrombocytopenia obtained from six patients. Sensitivity of this measurement as a test for quinidine purpura was found to be comparable to that of quantitative complement fixation and its use as an adjunct in the diagnosis of drug purpura is proposed.