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Observations on Recipient Plasma Hemoglobin Concentration after Transfusion with Glycerolized Frozen Blood
Author(s) -
Valeri C. R.
Publication year - 1965
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1965.tb01133.x
Subject(s) - hemoglobin , albumin , medicine , isotonic , whole blood , blood transfusion , saline , sodium , blood plasma , anesthesia , chemistry , organic chemistry
Recipient plasma hemoglobin was measured prior to, during, and following infusions of deglycer‐olized red blood cells resuspended in autologous plasma, 5 per cent outdated albumin resuspension medium, and isotonic saline. Blood collected in ACD solution and stored at 4 C was studied in a similar manner. The effect of aggregation and disaggregation of erythrocytes on the recipient plasma hemoglobin was observed. Observations in 12 nonsurgical recipients indicate that the mode of removal of nonviable deglycerolized erythrocytes is primarily through an extravascular mechanism without detectable hemoglobinemia. The aggregation of erythrocytes in either ACD blood or deglycerolized, reconstituted blood with 5 per cent dextrose and water and their disaggregation with 0.9 per cent sodium chloride in a common channel of intravenous tubing produced no unexplained elevation of the recipient plasma hemoglobin. In seven recipients studied, no abnormal antibodies were detected following repeated transfusions of deglycerolized erythrocytes over a period of time.