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Somatic Mutation Affecting the Rhesus and Duffy Blood Group Systems
Author(s) -
Jenkins W. J.,
Marsh W. L.
Publication year - 1965
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1965.tb01129.x
Subject(s) - somatic cell , mutation , blood group antigens , population , gene , genetics , biology , antigen , red blood cell , immunology , andrology , medicine , environmental health
A normal blood donor has been encountered whose red cell grouping tests showed a mixed cell population of CDe/cde, Fy(a+) and cde/cde, Fy(a—) cells. A family study revealed that the cde/cde, Fy(a—) cell population could not have arisen through a normal genetic pathway and reasons are given for suggesting that a gene mutation had occurred. As both Rhesus and Duffy genes are affected, it is concluded that the mutation has modified a common gene involved at some stage in the development of both blood group antigens.