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Relationships between Blood Group Agglutinogens: Role of Sialic Acids
Author(s) -
Rule Allyn H.,
Boyd William C.
Publication year - 1964
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1964.tb02904.x
Subject(s) - neuraminic acid , receptor , sialic acid , isoantigens , red blood cell , chemistry , glycoprotein , antigen , red cell , biochemistry , blood group antigens , phenotype , biology , immunology , medicine , gene
Various sialic acids have been found to inhibit a number of hemagglutinating sera and lectins at p H 7. The observations indicate that N‐acetyl neuraminic add may be a functional constituent of the M, N, and D receptors. It is suggested that many, perhaps most, of the different erythrocyte receptors are interrelated structurally. Isolated blood group substances from human erythrocytes should be considered and tested in terms of the complete phenotype of the cells from which they are extracted. Thus, attempts to isolate “pure” specific A, B, M, N, D, etc., antigens from erythrocytes may be based on an unrealistically idealized and simplified picture of the detailed structure of the red cell surface.