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A “New” Rh Antibody (Anti‐Rh 26) which Detects a Factor Usually Accompanying hr‘
Author(s) -
Huestis Douglas W.,
Catino Mary Lu,
Busch Shirley
Publication year - 1964
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1964.tb02900.x
Subject(s) - rh blood group system , typing , phenotype , antibody , heterozygote advantage , blood typing , blood type (non human) , abo blood group system , isoantibodies , microbiology and biotechnology , medicine , immunology , chemistry , andrology , biology , allele , genetics , gene , biochemistry
A serum (J.D.) obtained from a donor of type Rh 1 Rh 1 (CCDee) was determined by the usual studies to be anti‐hr‘(c). It was eventually found, however, to give no reaction with an occasional blood sample which was hr’‐positive with all other typing serums. Cells of the latter phenotype (J.D.‐negative, hr‘‐positive) show a weakened expression of both hr’ and hr(f). The characteristic is inherited, is expressed in the heterozygote, and has not yet been found in the homozygous form. The J.D. serum has been designated as anti‐Rh26, hence the Rh phenotype identified by it is Rh: w 4 , w 6“, ‐26 . Most hr‘‐positive red blood cells also possess Rh26. One donor possessing Rh26 but not hr’ has been detected.