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A Second Example of “Naturally Occurring” Anti‐M Antibodies in a Twin, with Remarks on Atypical Antibodies as Possible Aids in the Identification of Chimeras
Author(s) -
Kuhns William J.
Publication year - 1964
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1964.tb02843.x
Subject(s) - antibody , biology , karyotype , immunology , chimera (genetics) , red blood cell , chromosome , isoantibodies , blood grouping , blood cell , blood group antigens , genetics , abo blood group system , gene
“Naturally occurring” anti‐M antibodies were found in the serum of a ten‐month‐old type N female Negro twin (designated twin A), as revealed upon blood testing by a discrepancy between the cell blood group and the reverse blood group. The other twin, a male (designated twin B) did not possess this antibody. No specific cause for its presence could be determined although it was of interest that both the mother and the other twin were type MN. The possibility is discussed that anti‐M, although not indicative of chimerism in the corresponding twin, may have signalled the presence of chimerism in twin B. However, red blood cell chimerism was not established. A technic of karyotyping also failed to reveal cell mixtures upon difference in sex chromosome morphology.