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Successful Prevention of Experimental Rh Sensitization in Man with an Anti‐Rh Gamma 2 ‐Globulin Antibody Preparation: A Preliminary Report
Author(s) -
Freda Vincent J.,
Gorman John G.,
Pollack William
Publication year - 1964
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1964.tb02824.x
Subject(s) - sensitization , gamma globulin , medicine , antibody , rh blood group system , intramuscular injection , saline , rh isoimmunization , globulin , antigen , immunology , pregnancy , biology , fetus , genetics
An anti‐Rh gamma 2 ‐globulin antibody preparation has been developed which can be administered intramuscularly and appears to be both safe and effective in the prevention of experimental Rh sensitization. Nine unsensitized Rh‐negative male volunteers were challenged once a month for five successive months with intravenous injections of 2 ml. of Rh‐positive blood. Four of these nine volunteers were passively protected each month with intramuscular injections of 5 ml. of this antibody preparation, administered 24 hours prior to the antigenic challenge. Three months after the last injection the passively acquired Rh antibodies were no longer demonstrable (by either the saline or indirect antiglobulin technics) in any of the four protected subjects and there was no sign of active antibody production six months after the last injection, whereas four of the five controls were all strongly sensitized.