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Report on a Family with Six Tj a ‐Negative Siblings
Author(s) -
Stern Kurt,
Busch Shirley
Publication year - 1963
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1963.tb05910.x
Subject(s) - medicine , transplacental , pregnancy , blood type (non human) , pediatrics , hemolytic disease of the newborn (abo) , disease , obstetrics , cord blood , antibody , fetus , hyaline , family studies , family history , immunology , placenta , blood typing , pathology , biology , genetics
A pregnant woman for whom it was not possible to find compatible blood needed for transfusion, was found to have the rare blood type pp (Tj a ‐negative) with anti‐P + P 1 antibodies in her serum. The patient was one of ten living sibs among whom four brothers and one sister had the same rare type as the proposita. Results of genetic and immunohematologic studies on this sibship and their parents were presented. The obstetric history of the proposita included three miscarriages. The fourth pregnancy, terminated by cesarean section, resulted in a premature infant, whose death was attributed to hyaline membrane disease. The fifth pregnancy ended with a full‐term normal infant who remained free of disease. Positive direct antiglobulin tests were obtained with cord blood specimens of both infants, indicative of transplacental transfer of the maternal anti‐P + P 1 antibodies. However, manifest hemolytic disease of the newborn did not develop in either infant. The observations made in this study were compared with data recorded in the literature on this subject and discussed in relation to clinical and laboratory problems arising from the presence of the rare blood type p.