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Viral Hepatitis Associated with Sub‐human Primates *
Author(s) -
Hillis William D.
Publication year - 1963
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1963.tb04673.x
Subject(s) - virology , hepatitis , virus , biology , immunology , viral hepatitis , hepatitis a virus , hepatitis virus , non human , hepatitis c virus , medicine , political science , law
Recent epidemiologic evidence has accumulated indicating that certain chimpanzees and other primates act as carriers of human hepatitis virus. Outbreaks of human hepatitis in which primates have been so implicated are summarized in this paper, and the significant epidemiologic findings are emphasized. Isolations of viral agents from the stools of 25 suspect animals, together with experimental attempts to characterize some of the properties of these agents and to relate them to human hepatitis virus, are described. The paper also gives biochemical and histologic evidence for pathologic involvement of the livers of some of the implicated primates, as a possible consequence of infection by hepatitis virus. Such findings suggest that certain primates may prove useful as experimental hosts for human hepatitis virus.