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Blood Platelets and Extracorporeal Circulation *
Author(s) -
Salzman Edwin W.
Publication year - 1963
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1963.tb04642.x
Subject(s) - platelet , extracorporeal circulation , perfusion , cardiopulmonary bypass , heparin , medicine , platelet adhesiveness , cardiology , anesthesia , platelet aggregation
Platelet adhesiveness has been studied in patients undergoing cardiopulmonary bypass. Conventional doses of heparin do not alter platelet adhesiveness. With the onset of perfusion, however, there is a precipitous fall in platelet count and in the adhesiveness of those platelets remaining. It appears that a circulating inhibitor of platelet sticking is present during perfusion. In most cases, this defect gradually disappears after perfusion. In a few patients with excessive bleeding, persistent abnormalities in platelet adhesiveness have been demonstrated.