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Three Members of One Family with the Phenotype i; One with an Anti‐I Antibody
Author(s) -
Claflin Alice J.
Publication year - 1963
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1963.tb04628.x
Subject(s) - antibody , phenotype , antigen , cord blood , immunology , isoantibodies , typing , medicine , biology , genetics , gene
In 1956, the anti‐I antibody was first described in connection with a cold hemolytic anemia. Since that time, healthy individuals have been found with the anti‐I antibody and the phenotype i. The anti‐I antibody reacts best at 4 C. and weakly or not at all with cord blood and erythrocytes of known phenotype i. The I antigen is unstable with increasing age of the cell. Survival study with I incompatible erythrocytes labeled with Cr 51 is reported for the first time and shows a T1/2 of 6.5 days. The identification of the anti‐I antibody in this patient and subsequent typing of his family has supplied three names for the rare donor file. A complete family study would be of interest and could possibly further establish evidence of genetic control of the Ii antigens.