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R°( D ‐ ‐) in Two Japanese Families with a Note on Its Genetic Interpretation
Author(s) -
Yokoyama Mitsuo,
Solomon Joel M.,
Kuniyuki Masayori,
Stroup Marjory
Publication year - 1961
Publication title -
transfusion
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.045
H-Index - 132
eISSN - 1537-2995
pISSN - 0041-1132
DOI - 10.1111/j.1537-2995.1961.tb00058.x
Subject(s) - proband , interpretation (philosophy) , genetics , cistron , antibody , mutation , biology , gene , medicine , philosophy , linguistics , escherichia coli
Members of two Japanese families residing in the same small village were shown to carry the ( D ‐ ‐) gene when antibodies in the sera of the two probands presented a crossmatching problem. A study of their sera revealed a complex array of Rh antibodies, including perhaps anti‐ Hr 8 . The ( D ‐ ‐) complex is considered to have arisen by mutation of several sub‐elements (mutons) according to the cistron theory of genetopology.