Open AccessPrenatal Effects of Antiepileptic Drugs
Author(s) -
Ikonomidou Chrysanthy
Publication year - 2010
Publication title -
epilepsy currents
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.415
H-Index - 22
eISSN - 1535-7511
pISSN - 1535-7597
DOI - 10.1111/j.1535-7511.2009.01350.x
Subject(s) - synaptogenesis , neurogenesis , neuroscience , brain development , epilepsy , neurotransmitter , synaptic plasticity , biology , medicine , central nervous system , receptor
Antiepileptic drugs (AEDs) target ion channels and neurotransmitter systems in the brain; these same targets are responsible for regulation of processes essential for brain development. In this review, experimental findings on adverse effects of AEDs in the developing mammalian brain will be presented, including interference with physiological apoptotic cell death, cell proliferation and migration, neurogenesis, axonal arborization, synaptogenesis, and synaptic plasticity.