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Effect of Pregabalin in the Treatment of Refractory Neck Pain: Cost and Clinical Evidence from Medical Practice in Orthopedic Surgery and Rehabilitation Clinics
Author(s) -
FlórezGarcía Mariano,
CeberioBalda Félix,
MoreraDomínguez Carles,
Masramón Xavier,
Pérez María
Publication year - 2010
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/j.1533-2500.2010.00430.x
Subject(s) - pregabalin , medicine , refractory (planetary science) , prospective cohort study , orthopedic surgery , neck pain , physical therapy , medical costs , anesthesia , surgery , health care , alternative medicine , physics , pathology , astrobiology , economics , economic growth
Background: The study aims to prospectively analyze the effect of adding pregabalin upon costs and consequences in the treatment of refractory neck pain under routine medical practice. Methods: A secondary analysis was carried out including patients over 18 years, with 6‐month chronic neck pain refractory from a prospective, naturalistic, 12‐week two‐visit study. The analysis compared patients adding pregabalin to its therapy vs. usual care. Severity of pain, healthcare resources utilization, lost workday equivalents (LWDE) because of pain, and related cost‐adjusted reductions were assessed. Results: A total of 312 patients (65.3% women, age 54.2 [12.1] years), 78.2% receiving pregabalin, were analyzed. Adding pregabalin was associated with higher adjusted reduction in pain severity: −3.2 (1.8) points, 55.4% responders (≥ 50% baseline pain reduction) vs. −2.3 (2.0) and 38.2%, respectively; P < 0.001, yielding a higher reduction in mean LWDE: 20.1 (23.1) vs. 8.2 (22.4); P = 0.014, which produced significant reductions in the indirect components of cost: €1,041.0 (1,222.8) vs. €457.3 (1,132.1), P = 0.028. The costs of pregabalin (€309.8 [193.2] vs. €26.4 [79.6], P < 0.001) was offset by higher numerical reductions in the other components of costs, producing similar direct cost reductions in both groups at the end of the study: €66.8 (1,080.8) and €143.5 (1,922.4), respectively; P = 0.295. Conclusion: Compared with usual care, the addition of pregabalin to treat refractory neck pain seems to be associated with a higher reduction in pain severity and lost work‐days equivalents, which in turn results in a greater reduction of the indirect components of cost while maintaining similar healthcare cost levels despite its higher price.