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Pregabalin for Pain Management
Author(s) -
Gajraj Noor M.
Publication year - 2005
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/j.1533-2500.2005.05205.x
Subject(s) - pregabalin , medicine , pain management , anesthesia
Pregabalin is a new analog of the neurotransmitter gamma‐aminobutyric acid (GABA). It is an alpha 2 ‐delta (α 2 ‐δ) ligand that has analgesic, anticonvulsant, and anxiolytic activity. Alpha 2 ‐delta is an auxiliary protein associated with voltage‐gated calcium channels. Pregabalin binds potently to the α 2 ‐δ subunit resulting in modulation of calcium channels and reduction in the release of several neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P. This review discusses the pharmacology of this medication as well as available studies in patients.