Premium
Pharmacology (83)
Author(s) -
Warren P.M.,
Taylor J.H.,
Nicholson K.E.,
Wraith P.K.,
Drummond G.B.
Publication year - 2001
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/j.1533-2500.2001.1011-83.x
Subject(s) - tramadol , hypercapnia , placebo , medicine , anesthesia , hypoxia (environmental) , ventilation (architecture) , hypoxic ventilatory response , respiratory system , analgesic , acidosis , oxygen , mechanical engineering , chemistry , alternative medicine , organic chemistry , pathology , engineering
Influence of tramadol on the ventilatory response to hypoxia in humans. (University of Edinburgh, Edinburgh, United Kingdom) Br J Anaesth 2000;85:211–216. In this study, the effect of tramadol on the ventilatory response to 7 min acute isocapnic hypoxia during steady mild hypercapnia in 14 healthy volunteers (7 male, 7 female) was studied. The acute hypoxic response was measured before and 1 h after oral placebo or tramadol (100 mg). After tramadol, ventilation during mild hypercapnia (mean 11.28 liters min −1 ) was significantly less ( P < 0.05) than during placebo baseline (13.93 liters min −1 ), tramadol baseline (14.63 liters min −1 ), or after placebo (14.9 liters min −1 ), confirming that tramadol has a small depressive effect on the hypercapnic ventilatory response. There was no significant difference in the hypoxic ventilation/Sp o2 response measured during the placebo baseline (0.99), placebo (1.18), tramadol baseline (0.78) or tramadol (0.68) runs. These data suggest that tramadol does not depress the hypoxic ventilatory response.