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Neurology (62)
Author(s) -
Andersson C.,
Lithner F.
Publication year - 2001
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/j.1533-2500.2001.1011-62.x
Subject(s) - medicine , forefoot , neurology , surgery , ankle , pediatrics , complication , psychiatry
Signs of neuropathy in the lower legs and feet of patients with acute intermittent porphyria. (University of Umeå, Umeå, Sweden) J Intern Med 2000;248:27–32. A total of 356 patients were registered and 339 of them (95%) participated in this neuropathy study. The chronic neurological signs were symmetrical and similar to those in type 1 diabetic patients. Significant impairment was found concerning perception, EDB test, lower leg pain, ankle and knee tendon reflexes, but not concerning dry feet, loss of forefoot arch and hammer toes, on comparing patients with manifest versus latent acute intermittent porphyria (AIP). The neurological signs were more severe in the diabetic patients (n = 298). Five AIP patients had permanent quadriplegia after severe attacks. Conclude that patients with manifest AIP had significantly more signs of distal chronic, symmetrical neuropathy of the axonal type than did patients with latent AIP. More grave neurological lesions appear to develop after severe attacks.