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Neurology (51)
Author(s) -
Van Hilten J.J.,
Van de Beek W.J.T.,
Roep B.O.
Publication year - 2001
Publication title -
pain practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 58
eISSN - 1533-2500
pISSN - 1530-7085
DOI - 10.1111/j.1533-2500.2001.1011-51.x
Subject(s) - medicine , dystonia , neurology , complex regional pain syndrome , tonic (physiology) , anesthesia , psychiatry
Regional pain syndrome: a distinct clinical entity associated with HLA‐DR13. (Leiden University Medical center. Leiden, The Netherlands) Ann Neurol 2000;48:113–116. This report discussed 26 patients with a distinct phenotype of complex regional pain syndrome that progressed toward a multifocal or generalized tonic dystonia. The dystonia initiated distally, involved mainly flexor muscles, and was associated with sensory and autonomic symptoms. Dryness of the eyes or mouth and bladder and bowel disturbances were frequently reported. There was no increase in the familial prevalence of autoimmune‐mediated disease. Compared with controls, a significant elevation of HLA‐DR13 was found in the patients. Thus, HLA‐DR13 may be a factor indicating susceptibility to this distinct phenotype of complex regional pain syndrome.