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Perioperative Administration of Antimicrobials During Tibial Plateau Leveling Osteotomy
Author(s) -
Nazarali Alim,
Singh Ameet,
Weese J. Scott
Publication year - 2014
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2014.12269.x
Subject(s) - medicine , perioperative , antimicrobial , staphylococcus pseudintermedius , cefazolin , surgery , antibiotics , retrospective cohort study , dosing , anesthesia , staphylococcus , staphylococcus aureus , chemistry , organic chemistry , biology , bacteria , microbiology and biotechnology , genetics
Objective To evaluate perioperative antimicrobial administration during tibial plateau leveling osteotomy (TPLO) in dogs at the Ontario Veterinary College Health Sciences Centre. Study Design Retrospective case series. Animals Dogs (n = 184) that had TPLO (n = 226). Methods Medical records were reviewed and data collected included timing and dosage of pre, intra, and postoperative antimicrobial administration, method of stifle inspection, duration of surgery, duration of anesthesia, development of surgical site infection (SSI), microbiological investigation, implant removal, and possible comorbidities. Univariable analysis was conducted, followed by stepwise forward logistic regression to determine factors associated with SSI. Results Of the 225 cases administered perioperative antimicrobials, 96 (42.5%) received appropriate perioperative antimicrobial prophylaxis based on target times for preoperative and intraoperative dosing. Postoperative antimicrobials were administered to 54 (23.9%) of cases. Surgical site infection was documented in 30 (13.3%) cases. Staphylococcus pseudintermedius was isolated from 15/17 (88.2%) SSI from which a bacterium was isolated, with 6/15 (40%) being methicillin‐resistant Staphylococcus pseudintermedius (MRSP). Postoperative administration of antimicrobials was protective for SSI (OR 0.1367; P = .0001; 95% CI = 0.021, 0.50). Duration of anesthesia time was associated with the likelihood of development of SSI (OR = 1.0094; P = .001; 95% CI = 1.00, 1.02). Conclusion Current practices for administration of antimicrobial prophylaxis during TPLO can be improved. There was no association between timing of antibiotic administration that was inconsistent with the target and development of SSI. Further study into risk factors of TPLO SSI is required.