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Autologous Platelet Gel to Treat Chronic Decubital Ulcers: A Randomized, Blind Controlled Clinical Trial in Dogs
Author(s) -
Tambella Adolfo Maria,
Attili Anna Rita,
Dini Fabrizio,
Palumbo Piccionello Angela,
Vullo Cecilia,
Serri Evelina,
Scrollavezza Paolo,
Dupré Gilles
Publication year - 2014
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2014.12148.x
Subject(s) - medicine , surgery , wound healing , randomized controlled trial , clinical trial , platelet , clinical efficacy , double blind , anesthesia , pathology , alternative medicine , placebo
Objective To determine the efficacy of topical application of the autologous platelet gel (PG) in canine chronic protracted decubital ulcers. Study Design Prospective, randomized, blind controlled clinical trial. Animals Dogs (n = 18) with bilateral chronic wounds caused by protracted decubitus ulcers. Methods For each dog, wound side was randomized to receive either platelet gel (group PG) every 5 days for 5 dressing changes, or paraffin gauzes dressings (group C), as negative control. Wound healing and wound surfaces were compared at admission and then evaluated every 5th day, until day 25. Outcome variables were: open wound area, reduction of open wound surface compared to admission and to each preceding dressing change, time to complete epithelialization. Results Significant differences in healing process were observed at day 5 and continued throughout the entire study period ( P < . 00001). At 25 days, mean percent reduction in wound area was 93.5% in group PG and 13.2% in group C ( P < .00001). Conclusions Appropriately prepared autologous PG, an inexpensive, readily available blood derivative, applied topically results in more rapid healing of chronic non‐healing decubital ulcers in dogs than those treated by use of paraffin‐impregnated gauzes.