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Intra‐Articular Pharmacokinetics of a Gentamicin Impregnated Collagen Sponge in the Canine Stifle: An Experimental Study
Author(s) -
Hayes Galina M.,
Gibson Thomas W.G.,
Moens Noel. M.M.,
Monteiro Beatriz,
Johnson Ron J.
Publication year - 2014
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2014.12115.x
Subject(s) - gentamicin , medicine , pharmacokinetics , synovial fluid , aminoglycoside , antibiotics , anesthesia , urology , pathology , microbiology and biotechnology , osteoarthritis , alternative medicine , biology
Objective To investigate local and systemic pharmacokinetics of gentamicin after intra‐articular implantation of a gentamicin impregnated collagen sponge (GICS) in the inflamed canine joint. Study Design Descriptive repeated measures experimental study. Animals Dogs (n = 9). Methods Stifle joint inflammation was caused by urate injection. Twenty‐four hours later a GICS (gentamicin dose, 6 mg/kg) was arthroscopically implanted. Synovial fluid and plasma gentamicin concentrations were measured for 14 days after implantation, and pharmacokinetic parameters modeled using statistical moment analyses. Results Intra‐articular gentamicin concentrations fell to sub‐MIC for Staphylococcus sp. (4 µg/mL) by 22.4 hours (95% CI: 18.6–26.2) after sponge implantation. C max synovial was 2397 µg/mL (95%CI: 1161–3634 µg/mL) at 1.2 hours (95%CI: 0.5–1.8 hours). Plasma gentamicin concentrations achieved levels of C max plasma = 8.0 µg/mL (95%CI: 6.1–10.0 µg/mL) at 1.5 hours (95%CI: 0.8–2.1) after GICS placement and fell below target trough of 2.0 µg/mL by 5.6 hours (95%CI: 4.7–6.5 hours) after GICS placement. Conclusions Intra‐articular gentamicin concentration after GICS placement at an IV‐equivalent dose reached high levels and declined rapidly. The maximum plasma levels attained were ∼1/3 of the recommended sub‐toxic target for people after parenteral gentamicin administration.