Premium
In Vivo Effects of a Single Intra‐Articular Injection of 2% Lidocaine or 0.5% Bupivacaine on Articular Cartilage of Normal Horses
Author(s) -
Piat Perrine,
Richard Hélène,
Beauchamp Guy,
Laverty Sheila
Publication year - 2012
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2012.01039.x
Subject(s) - bupivacaine , medicine , lidocaine , cartilage , anabolism , saline , local anesthetic , aggrecan , anesthesia , placebo , osteoarthritis , articular cartilage , anatomy , pathology , alternative medicine
Objective To assess the effects of an intra‐articular ( IA ) lidocaine or bupivacaine injection on synovial fluid ( SF ) biomarkers of cartilage metabolism. Study Design Experimental. Animals Horses (n = 6). Methods The study had 2 components, each with an identical design: the first arm assessed the effects of bupivacaine (0.5%) IA in the intercarpal joints and, after a 2‐week washout period, the second was conducted to evaluate the effects of IA lidocaine (2%) in the tarsocrural joints. The mares were randomly assigned to receive the test local anesthetic in the target joint or the placebo (0.9% NaCl) in the contralateral joint. After a 2‐week washout period, treatments were reversed, yielding 6 joints for each treatment. SF samples were collected for measurement of biomarkers of cartilage metabolism. Results IA bupivacaine or lidocaine induced a significant increase in both markers of cartilage matrix synthesis ( CS 846–aggrecan and CP II–type II collagen) suggesting an anabolic effect. Bupivacaine also resulted in an unanticipated decrease in both collagen degradation markers ( C 2 C and C 1,2 C ). Conclusions These results reveal an anabolic effect of single IA injections of local anesthetics on cartilage metabolism. Although collagen degradation biomarker results were not increased, it is possible that the anabolic response is because of an undetected cartilage insult, and requires further investigation.