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Bone Resorption Markers and Dual‐Energy X ‐Ray Absorptiometry in Dogs with Avascular Necrosis, Degenerative Joint Disease, and Trauma of the Coxofemoral Joint
Author(s) -
Youkhanna David,
Griffon Dominique J.,
Fredericks Page,
Schaeffer David,
Fan Timothy M.,
Jasiuk Iwona M.
Publication year - 2012
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2011.00991.x
Subject(s) - medicine , avascular necrosis , femoral head , n terminal telopeptide , femoral neck , bone resorption , bone mineral , dual energy x ray absorptiometry , urology , urine , pathology , surgery , osteoporosis , alkaline phosphatase , biochemistry , chemistry , osteocalcin , enzyme
Objectives To compare the ability of N ‐terminal telopeptide ( NT x) assays and dual‐energy x‐ray absorptiometry ( DEXA ) to detect bone resorption in dogs with nonneoplastic bone lysis and evaluate the correlation between these diagnostic tools. Study Design Prospective, cross‐sectional clinical study. Animals Dogs (n = 35; 39 femoral heads) that had femoral head and neck ostectomy and 6 cadaver specimens from healthy immature small dogs. Methods Small dogs with avascular necrosis (n = 12), a reference group of small dogs (7), large dogs with degenerative joint disease ( DJD ; 10), and large dogs with trauma (10) were studied in addition to 6 femoral heads harvested from 6 small immature and healthy dogs euthanatized for reasons unrelated to this study. Densitometric measurements of femoral heads, urine NT x excretion, and serum NT x concentration were compared between groups. Results Avascular necrosis resulted in a decrease in bone mineral density ( BMD ) (0.18 ± 0.01 g/cm 2; P < .01) of the femoral head and elevation of serum NT x (159.3 ± 59.4 nM; P = .03) compared to small dog controls (0.28 ± 0.02 g/cm 2 ; 18.7 ± 1.83 nM, respectively), but did not seem to affect urine NT x. DJD in large dogs did not seem to affect any of the densitometric parameters evaluated. BMD ( P = .03) and serum NT x ( P = .04) were lower in small compared to large dogs. Serum NT x and densitometric measurements correlate inversely with each other ( P = .001) but neither test correlated with urine NT x ( P = .8–.9). Conclusion Serum NT x levels vary with dog size but seem to correlate better with BMD better than urine NT x excretion in dogs with nonneoplastic bone resorption.