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Outcome after Renal Transplantation in 26 Dogs
Author(s) -
Hopper Kate,
Mehl Margo L.,
Kass Philip H.,
Kyles Andrew,
Gregory Clare R.
Publication year - 2012
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2011.00924.x
Subject(s) - medicine , transplantation , medical record , retrospective cohort study , kidney transplantation , surgery , disease , cause of death , survival analysis
Objectives To evaluate clinical outcome in dogs after renal transplantation and determine predictors of outcome. Study Design Retrospective case series. Animals Dogs ( n = 26) that had renal allograft transplantation. Methods Medical records (1994–2006) of 26 consecutive cases of dogs that had kidney transplantation were reviewed. History, signalment, pre‐ and postoperative clinicopathologic and monitoring variables, postoperative complications, immunosuppressive therapy, and survival were recorded. Results Median survival was 24 days (range, 0.5 to 4014 days) with a probability of survival to 15 days of 50% and the 100‐day survival probability was 36%. Cause of death was attributed to thromboembolic disease in 8 dogs, infection in 6 dogs, and rejection in 1 dog. The only factor significantly associated with an increased likelihood of death was increasing age at time of surgery ( P = .024). Conclusions Canine renal transplantation in clinical patients is associated with a high morbidity and mortality and increasing recipient age has a negative association with outcome. Thromboembolic complications are a major cause of death in the immediate postoperative period and effective anticoagulation protocols may greatly improve survival in the future.