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Clinical Use of Recombinant Human Bone Morphogenic Protein‐2 in a Whooping Crane ( Grus americana )
Author(s) -
SAMPLE SUSANNAH,
COLE GRETCHEN,
PAULMURPHY JOANNE,
HARTUP BARRY K.,
CLYDE VICTORIA,
SEEHERMAN HOWARD J.,
SCHAEFER SUSAN
Publication year - 2008
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2008.00419.x
Subject(s) - medicine , bone morphogenetic protein , bone healing , surgery , callus , grus (genus) , population , biochemistry , chemistry , genetics , environmental health , biology , gene
Objective— To report use of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) as adjunctive therapy for treatment of a comminuted, open, proximal humeral fracture in an avian species. Study Design— Clinical report. Animals— A 3.5‐month‐old male whooping crane ( Grus americana ). Methods— An open, severely comminuted humeral facture was stabilized with an intramuscular (IM) pin/type IA external skeletal fixator with tie‐in configuration. rhBMP‐2 was applied in a calcium phosphate matrix (CPM) paste directly to the fracture site as a bone graft substitute. Radiographic evidence of bone healing was monitored for 14 weeks. Results— Substantial bony callus was evident at 4 weeks and at 8 weeks there was bridging callus with obvious bony remodeling. The fixation was destabilized at 9 weeks by IM pin removal, bone healing progressed and the fixator was removed at 11 weeks. By 14 weeks both cortices had been re‐established with continued callus remodeling evident. Conclusion— rhBMP‐2, applied in a CPM paste, was used as a bone graft substitute in the treatment of a comminuted, open humeral fracture in a whooping crane. Clinical Relevance— Use of rhBMP‐2/CPM should be considered in treatment of avian fractures.