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Effect of Nephrotomy on Renal Function and Morphology in Normal Cats
Author(s) -
KING MICHAEL D.,
WALDRON DON R.,
BARBER DON L.,
LARSON MARTHA M.,
SAUNDERS GEOFFREY K.,
TROY GREGORY C.,
ZIMMERMANPOPE NANCY,
WARD DAN L.
Publication year - 2006
Publication title -
veterinary surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.652
H-Index - 79
eISSN - 1532-950X
pISSN - 0161-3499
DOI - 10.1111/j.1532-950x.2006.00219.x
Subject(s) - medicine , cats , renal function , urinalysis , kidney , urology , clinical significance , urine
Objective— To assess effects over 12 weeks of bisection nephrotomy on renal function, size, and morphology in cats. Study Design— Controlled, randomized, blinded experiment. Sample Population— Ten adult female cats. Methods— Glomerular filtration rate (GFR), determined by quantitative renal scintigraphy using 99m Technetium‐diethylenetriamine‐pentaacetic acid, urinalysis, urine culture, and ultrasonographic measurement of renal size were performed preoperatively. Left or right nephrotomy (5 cats/group) was performed. Total and individual kidney GFRs were determined at 2, 28, and 84 days, ultrasonographic measurements at 28 and 86 days, and ultrasound‐guided biopsy at 86 days. Results— No significant differences in mean GFR and kidney size of operated versus unoperated kidneys were observed. Individual GFR and renal size of all except 1 cat remained within normal limits. Two cats had evidence of transient ureteral obstruction in the immediate postoperative period. No significant, generalized histologic abnormalities were observed. Conclusions— Bisection nephrotomy in normal cats does not adversely affect renal function or morphology during the initial 12 weeks. Clinical Relevance— Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in cats with pre‐existing renal insufficiency are needed to ensure adverse effects would not occur in clinical cases where this surgical procedure is warranted.